Assembly of an artificial ovary combining isolated human ovarian follicles, fibrin and a textile pocket
The objective of this project is to develop a 3D biodegradable matrix to graft an autologous ovarian tissue or isolated follicles in patients with impaired fertility following a gonadotoxic treatment. This biofunctional fibrin-based matrix will limit the follicular loss due to post-transplant ischaemic stress and will help to induce the formation of an extracellular ovarian-like matrix by promoting cell migration, cell proliferation and vascularization. In addition, a biodegradable textile pocket will also be developed to contain the tissue scaffold and to efficiently suture the graft at the implantation site.
Consortium
Companies: Baxter R&D Europe (coordinator), SMI
Universities: UCL, ULg
Research centre: Centexbel
