Projects
View a list of current and complete projects from BioWin and its members.
BioWin’s members participate in a wide range of R&I collaborative projects. BioWin is involved in European projects with other international clusters.
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AERONEXT
Asthma and COPD (Chronic Obstructive Pulmonary Disease) are amongst the most common causes of mortality and morbidity worldwide, representing together the third largest medical market. Their prevalence is increasing due to the global industrial pollution. Inhaled therapies, the preferred treatment options, are made of a drug combined with a medical...
AEROVID
In order to improve the effectiveness of inhalation therapy and prevent the increasing prevalence of respiratory disease exacerbations, Aquilon (AQ) and Radiomics (RDX), together with the academic partners ULiège, ULB and UMONS (A.E., Academic Entities of the consortium) have decided to join their respective competences in the AEROVID project. The...
Allert
Handheld Allergens Detector The ALLERT aims to release on the market a practical, portable, and rapid diagnostic system to detect allergens in foods. This product answers to a growing need in food safety management due to increment of food allergies in population. All the production chain of agro-alimentary is targeted...
Arc Protonthérapie
Project co-led by MecaTech and BioWin. The project aims to develop an innovative variation of the classical technique of delivery of proton therapy by intensity modulation. This new technique is called "Arc Protontherapy". This new technique allows to deliver the dose continuously during rotation of the gantry. For the patient, Arc...
AVATAR²
Aortic VAlve TransApically Resected and Replaced Aortic stenosis affects about 2 % of the population aged over 65. This disease consists in a hardening of the cardiac valve that will reduce its capabilities during the opening and the closing. Nowadays, the reference treatment is an open heart surgery in order...
Be4OneW
The purpose of the Be4OneW project is to provide access to biopharmaceutical care (monoclonal antibodies, vaccines, etc.) to the greatest number of patients, whether in emerging countries or in our European countries, particularly in the event of a shortage or pandemic. To achieve this goal, the present project proposes a...
BENEFIT
The treatment of patients in clinical practice relies on the results of randomized clinical trials. The statistical methods currently used to test the treatment effects in such trials take into account a single criterion called "primary endpoint". This is an incomplete assessment of trial results, especially in oncology and chronic...
BIDMED
Application of « Big data » digital technologies in the healthcare sector BIDMED wishes to explore the applicability and use of « Big Data » digital technologies in the healthcare sector, with a specific objective of enhancing the accessibility to proton therapy, the advanced radiotherapy modality for which the Walloon...
BIOCLOUD 4.0
The health sector sees the emergence of new generations of innovative therapies, among which promising approaches are related to gene and cell therapies. This evolution often leads to the deployment of patient-centric processes, implying not only dramatic changes in the bio-production processes but also significant increases of the treatment costs....
Biofina
Development of inhaled synergetic combinations for the treatment of resistant respiratory infections The aim of BioFiNa is to develop inhaled synergetic combinations for the treatment of resistant respiratory infections. The development of germs which are increasingly resistant to antibiotics is a major public health problem. The arsenal of available antibacterials...
BioLine
Holographic Analyses Devices The objective of the BioLine project is to further validate and optimize Ovizio’s technology for cell culture monitoring allowing it to analyze in a non invasive and reliable way, key cell culture parameters like cell numbers, cell morphology, viability, distribution of cell sizes and the presence of...
BIOPTOS
3D Printed Biomaterials and OPTimized for Regeneration Oral Bone Bone regeneration is frequently used in dentistry especially in implantology. The use of biomaterials for bone regeneration or alveolar bone preservation is a reliable treatment option compared to autologous bone involving higher morbidity. However, the commercially available biomaterials for dental bone...
BoneRec
The BoneRec project aims to develop a new tissue-engineered product indicated for bone reconstruction. This ideal bone graft substitute will be biomechanically stable, resorbable and will have osteoconductive, osteogenic and osteoinductive properties. The biomechanical property will be provided by Cerhum's ceramic graft (coordinating company of the project) and the osteoconductive,...
Brainµ
Bacteria and Resistance to Antibiotics. Identification using Nanotechnology and Microfluidics The goal of this project is to develop an in vitro test to identify the pathogenic bacteria and resistance parameters to antibiotics commonly encountered in human bacteremia. Doctors need a quick test to define the rapidly the most adequate therapy....
Cantol
Development and validation of new molecules to restore the immune response against cancer cells Immunotherapy, based on therapeutic vaccination against antigens expressed by cancer cells, is at the present time a very promising approach. Its application is limited, however, due to mechanisms of immune suppression that are critical to control...
CARDIA-X
Nexeon MedSystems Belgium is developing an innovative and non-invasive neurostimulation product for the treatment management of patients suffering from atrial fibrillation (AF). AF is the most common arrhythmia diagnosed in clinical practice and is predicted to affect 17.9 million people in Europe by 2060 and 6–12 million people in the USA by 2050. ...
CardiAmmonia
Project co-led by MecaTech and BioWin Today, nuclear medicine PET (Positron Emission Tomography) also extends to neurology and cardiology. Nuclear cardiology uses noninvasive myocardial perfusion examination techniques to evaluate the pumping capacity of the heart and to detect the presence of ischemia or lesions. High quality imaging of PET scanners...
CE4BIG
The project CE4BIG – Cluster Excellence for Business Innovation and Growth in the Health Sector, was selected to receive funding under the EU COSME “European Cluster Excellence” initiative. MAIN OBJECTIVE The project aims to foster cluster collaboration on a European-wide scale. The ultimate objective is to strengthen both, clusters and SMEs, to...
Colvir
Development and validation of a local treatment for cervix cancer resulting from human papillomavirus infection The main objective of the project is the development of an effective and safe local treatment, of the lesions of the cervix induced by HPV infection. This project results from the identification of a medical...
CQintégré
The purpose of “CQintégré” is the development of a comprehensive system dedicated to the Quality Control (QC) of radioactive pharmaceuticals used in nuclear medicine procedures. This system will include various analytical techniques, including HPLC, UPLC, TLC, GC, pH measurement, optical tests, and gamma-spectrum analysis. These technologies will be implemented and...
D-CAF
The objective of the D-CAF project is to develop a measurement toolkit in order to meet the next dosimetric challenges linked to the marketing of new particle therapy systems and to advances in radiotherapeutic techniques. In this context, the main ambition of the D-CAF project is to push innovation in...
Deep
Drug-releasing electrode with enhanced properties This project is about the development of an implantable electrode with quantitative drug eluting capacity. Polypyrrole coating of platinum nanostructuresformsthe basis of thisinnovative technology. Two lines of application are foreseen: one is to exploit the release of an anti-inflammatory drug in order to limit the...
DNAVAC
Development and production of DNA vaccines without antibiotic resistance gene DNA vaccination seems to be a promising method of fighting diseases. For this application, plasmid DNA is injected into the subject (man or animal). This plasmid DNA encodes for an antigen that will be produced by the subject’s cells. In...
eLISA
For the past ten years, researchers and doctors have considered sleep as a major public health issue. In particular, sleep apnea syndrome is frequently cited. At each interruption of breathing, your heart and your brain are under stress. Night after night your sleep is disturbed, your quality of life is...
EMPEROR
Embolus permanent protector stent-filter Worldwide, stroke is the number three cause of death and the number one cause of adult disability. More women die of stroke than breast cancer. Today, there is no viable treatment for stroke. There are two kinds of strokes, ischemic which involves a clot (85% of...
EPT-1
(MecaTech R&I project, followed by BioWin) IBA, Jobs & Project partner and V2I with UCL and UNamur to define the future of Proton Therapy delivery techniques with FLASH and Grid Therapies. Proton therapy is the most advanced form of radiotherapy in the fight against cancer. The unique dose deposition enables...
FAR
When surgical removal is not possible, oncologists have few treatment options to offer their cancer patients. Trasis, Xpress Biologics, CMMI (ULB) and UMONS are embarking on the FAR (Fragments of Antibodies for Radioimmunotherapy) research project to promote the use of antibody fragments as carriers of radioactive isotopes. By using both the ability of antibody fragments to target tumours and...
FRISBY
Fast and Reliable ultra-sensitive Identification of Streptococcus B at deliverY Sepsis, pneumonia and sometimes meningitis caused by Group B Streptococcus (GBS) are the most common severe bacterial diseases in infants. They account for high morbidity and mortality rates; despite the extent of implemented prevention strategies, GBS is still the leading...
Frite@home
Development of a tele-rehabilitation device for Functional neuro Rehabilitation using Intensive Therapy and Evaluation at home for patients with brain lesions The objective of the FRITE@Home project, which brings together the partners Axinesis, Arsalis, UCLouvain and HELHa, is to develop a tele-rehabilitation device, the REAtouch Lite, helping children with cerebral...
Gage
Gallium-68 Automated Generator and Equipment En tomographie par émission de positons (TEP), le fluor 18F est largement utilisé en raison de ses propriétés chimiques et radiophysiques favorables. Néanmoins, il nécessite la proximité d’un cyclotron en raison de sa demi-vie de 110 minutes. Le gallium-68, avec sa demi-vie de 68 minutes,...
Gloria
Today, the emergence of genetic tests and falling costs make it possible to inform anyone about their propensity to develop a pathology, as well as the means of reducing the probability of its occurrence (primary prevention), its extent (secondary prevention) and the most effective treatments. However, a growing number of…
HoloCancer
Development of Innovative Holographic Cancer Markers The primary goal of the HoloCancer project is to develop an instrument for cancer diagnostics, together with its associated consumable, based on Ovizio Diagnostics’ holographic imaging platform technology. More specifically, the system will be dedicated to the analyses of cervical cancer samples that can...
Hope4PD
Discovery of new targets for the treatment of Parkinson’s disease The HOPE 4 PD project aims to validate two G protein coupled receptors (GPCRs), whose expression is altered in the striatum of patients with Parkinson's disease, as targets of drugs to treat neuro-degenerative diseases, Parkinson's disease being the first indication....
iCone
Human iPSC-derived Cortical Neurons for Research and Development. The project aims to make highly functional human cortical neurons from stem cells. Right now these cellular models, in combination with laboratory tests, provide a unique and novel platform bridging traditional laboratory tests and clinical testing in patients. Showing close resemblance to...
Improve
Optimization of the treatment with HepaMune in fibro-inflammatory chronic liver diseases The aim of the IMPROVE project is to develop a new cell therapy product that will be used for the treatment of fibro-inflammatory chronic liver diseases. The objective is to develop a product exhibiting increased immuno-modulatory and anti-inflammatory potential,...
Inteliphages
Development of a powerful therapy to fight antimicrobial resistance. The aim of the Inteliphages project is to develop dried and encapsulated phages in order to treat bacterial infections that are either resistant to antibiotics or for which antibiotics are not indicated for other reasons. The development of dried and encapsulated...
IT-Targets
Identification of drug candidates and biomarkers for immunotherapy (cancer and autoimmune diseases) IT-Targets project aims to identify innovative drugs candidates and biomarkers for cancer immunotherapy and auto-immune diseases in order to improve the response of patients to immunotherapy. The strategy is based on sampling human clinical samples, purify the different...
JOIN T-AIC
Development of new therapeutic approaches for the treatment of inflammatory mono-arthritis combining “novel” anti-TNF-α and viscoelastic scaffold Mono-arthritis is generally treated by intra-articular injections of corticosteroids or of hyaluronic acid. However, due to their limited efficacy, or due to their toxicity, injectable corticosteroids are only administered a few times, which...
KeyMarker
Identification of new types of biomarkers and tracers for the in vivo molecular imaging of the pancreatic Beta-cell mass The goal of KeyMarker is to identify new types of biomarkers that can be used as radiotracers for PET or SPECT imaging and potential quantification of the pancreatic Beta-cell mass. Such...
M2-TARGET
M2-Target aims to develop a non-invasive imaging method for the detection and quantification of M2 macrophages. This method is based on a new radiotracer (called 68Ga-ABSCINT-206) initially developed at the Vrije Universiteit Brussel (VUB). It is composed of a single-domain antibody fragment (also called "nanobodies") that recognizes a receptor (CD206)...
MAGIA
MAGIA, The European MedTech Alliance dedicated to supporting the internationalization of SMEs, brings together 4 poles of excellence: Lyonbiopôle (France), BioPmed (Italy), BioWin and Life Science Nord (Germany), and aims to achieve a solid and reciprocal understanding of the activities of the four clusters in order to strengthen their collaboration. In this context, each...
MAGIA2Market
MAGIA2Market follows on from the first phase of the MAGIA project which ended on December 31, 2019. The second phase, MAGIA2MArket, once again brings together the four main European MedTech clusters: bioPmed (coordinator, Piedmont), BioWin (Wallonia), Life Science Nord (Northern Germany) and Lyonbiopole (Auvergne-Rhône-Alpes) who are joining forces to pursue...
Mirror
Medical Resource Real-Time Optimizer The project was born from interactions betweenmembers ofthe young PALANTIRIS company and IBA, both companiesfacing the limitations of traditional workflow management techniques when it comes to orchestrate complex processes in a hospital service. Such processes involve numerous shared resources(rooms, diagnostics,treatment equipment,…) within stricttiming constraints and in...
Modular 01
Modular 01 project consists of the development of a new generation synthesizer dedicated to the production of radiopharmaceuticals used as diagnostic (tracers) or therapies. The system is made of different sub-modules for the radioisotope management, the labeling step, the post labeling chemistries and the final purification / formulation. These sub modules can...
Monitosed
The MONITOSED project aims to develop the first non-pharmacological sedation monitoring system for use in daily clinical practice. Currently, the standard for sedation of patients during medical procedures is pharmacological sedation. Several monitoring tools to assess the depth of anesthesia of the patient under pharmacological sedation are available on the...
NEMO
In the biopharmaceutical sector, the development of bio-processes requires significant investments in time and resources: these processes are generally obtained after numerous iterations aimed at determining the operational parameters and measurements allowing to characterize them. The NEMO project aims to support the development of these bio-processes through digital technologies: it...
Neofor
Creation of a technological platform to administer medicines by pulmonary route The aim of the NEOFOR project is to establish a consortium in Wallonia that will coordinate multidisciplinary technology groups to construct a new SME that will be able to design and realize original formulations created with new medical devices...
NeuroAtt
Development of a neuronal technology to detect and treat attention deficit hyperactivity disorder (ADHD) NeuroAtt aims to design novel electrophysiological diagnostic tools (EDT) and brain wave trainers (BWT) in attention deficit hyperactivity disorder (ADHD). It includes the development of methods to analyse multi-channel EEG recordings during sensorimotor and cognitive tasks...
Neuro Insights
10 million people worldwide are suffering from Parkinson's disease and this number is likely to double over the next 10 to 15 years. There is no cure yet. Parkinson's disease is the fastest growing neurodegenerative disease. The disease is complex, as over 60 symptoms can appear. A personalised care path is therefore critical for...
NeuroPV
Project co-led by the MecaTech and BioWin clusters The project deals with the subject of neurostimulation, one of the rapidly developing fields of medicine. The goal is to develop an implant where wires have been replaced by optical fibers and which also uses photovoltaic cells to convert monochromatic optical energy...
NucleoGlio
Glioblastomas are highly aggressive forms of brain cancer, posing a significant clinical challenge, especially in cases of recurrence following surgical resection. In this regard, a team of researchers has focused on the non-invasive liquid biopsy approach for both the initial diagnosis or recurrence of glioblastoma, as well as for the...
OncoMethylomic
New tools to diagnose cancer and optimize cancer treatments The goal of this project is to develop in vitro tests (I) to diagnose cancer and (II) personalize treatment, based on the detection of gene methylation. This project will mainly make it possible to determine some of these markers of methylation...
Ovart
Assembly of an artificial ovary combining isolated human ovarian follicles, fibrin and a textile pocket The objective of this project is to develop a 3D biodegradable matrix to graft an autologous ovarian tissue or isolated follicles in patients with impaired fertility following a gonadotoxic treatment. This biofunctional fibrin-based matrix will...
PARADIS
Pcr And RApid Detection Integrated System Sepsis strikes an estimated 900,000 adults in Europe (and 750,000 in the USA) annually, with a mortality rate reaching 35 percent. Effective treatment of such invasive bacterial infections is a major concern because of the increased incidence of antibiotic resistant pathogens. Thus, a rapid...
PROSPECT
Prostate cancer imaging by Positron Emission Computed Tomography Prostate cancer is nowadays a major clinical challenge: it is the most frequently diagnosed cancer in men in Western countries and the second leading cause of cancer death in men over 50 years old. The project objective is to develop a set...
PROUESSE
Clinical evaluation of a new personalized viscosupplementation treatment against osteoarthritis based on innovative biomaterials and a personalized medicine ICT platform. The objective of this project is the CE marking and marketing of a new treatment against osteoarthritis (OA). OA is a most common disease related to cartilage erosion and joint...
RadioTarget
New 188Re-radiolabelled monoclonal antibodies in the fight against liver metastases Early diagnosis of primary cancer, prior to any extension beyond the organ in which it was originally developed, usually allows treatment with surgical resection. However, significant proportions of patients with colorectal, breast or ovary cancers develop spread to the liver...
Rheumagene
Development of a new diagnostic method of arthritis The aim of this project is to validate the diagnostic value of transcriptomic and/or proteomic profiles of synovial material in early arthritis. It is based on preliminary data showing that gene expression profilesin synovial biopsiesfrom patients with arthritis are able to discriminate...
S3MARTMED
For the cluster, S3MartMed constitutes an opportunity to develop a partnership with 4 other European clusters of excellence - BioPmed (Italy), BioRegio STERN Management (Germany), Lyonbiopôle (France) and MedSilesia (Poland) - in order to identify in the medical technology sector: Future key investment priorities, Joint activities for the emergence of interregional collaborations (commercial...
Single Cells
Development of an innovative approach for the control of microbial subpopulation in bioprocesses. Wagralim R&I project, co-led by BioWin. Microbial populations, even those called clonal (genetically identical), are inherently heterogeneous. In the biotechnology industry, this heterogeneity affects the performance and reproducibility of bioprocesses based on the use of microorganisms. In...
SMART
Statistical Monitoring Applied to Research Trials While the detection of deliberate (fraud) or unintentional errors concern pharmaceutical and biotechnology companies enormously, there is currently no integrated and automated system to monitor the quality of data based on statistical tests and artificial intelligence or data mining. IDDI is a pioneer in...
SoftMed
Numerous studies have shown that the majority of medical errors are attributable to a problem of non-technical skills (communication and teamwork) rather than a lack of technical skills. However, most of the training and tools used in these studies are aimed at the acquisition of technical skills only. The SoftMed...
SPUTUMAI
Asthma is the most common chronic respiratory disease in the world. It is characterized by a non-infectious but exacerbated inflammation of the airways that severely limits patients' lung function, severely reducing their quality of life, and may even require hospitalization. In order to diagnose asthma and determine a treatment that...
StarfloPlus
Glaucoma Management Implant System Research on a next generation Glaucoma Management Implant System that incorporates the latest advances in biomaterials, MEMS sensor and electronics technologies. The goal of the implant system is to provide a novel combination of therapeutic and diagnostic benefits for glaucoma patients and caregivers, while significantly reducing...
StemVac
Innovative immunotherapy approaches to treat breast cancer patients Breast cancer is the most common malignancy in women and is the second leading cause of cancer deaths (after lung cancer). There is a clear medical need for more efficient breast cancer treatments in terms of distant recurrence and safety and tolerance....
Targetum
Chitosan-based Targeting Drug Delivery Systems (Cs-tDDS) and their Proof of Concept Today, the most efficient therapeutic approaches in cancer rely on targeting the tumoral cells in order to enhance the therapeutic effect of the drug, to decrease its dosage and to limit its side effects. The TARGETUM Project aims at...
Theramir
Development of a unique platform of specific exosomes: Proof of concept for the solid tumor treatment For many forms of solid tumors (e.g. brain tumors, osteosarcoma, mammary tumors, melanoma), resection of the tumor and treatment for cancer can lead to damage to the function or appearance of part of the...
TreatBest
Treatment of breast cancer with epigenetic specific tools The partners of the TREATBEST consortium are joining forces in order to leverage disruptive science in the field of personalized breast cancer treatment. The final product will be a CE-marked IVD test predicting the treatment benefit for patients with triple-negative breast cancer,...
Valostem
Development of new cell-based in vitro models for ADME/Toxicity screening, based on human adult progenitor/stem cells Characterization of a new drug candidate during preclinical evaluation includes, in addition to potency and safety an assessment of drug metabolism and pharmacokinetics. Drug metabolism studies require identification ofthe products of drug candidate metabolism,...
VapChip
Bacterial resistance assay in real time PCR on array for patients with Ventilator Associated Pneumonia (VAP) The aim of the project is a pre-validation of a new real time assay (VAP-technology) for the rapid detection of the bacterial species and their resistance in pneumonia. The assay was developed in order...
Vetphage
This project was conceived on the basis of the important economic and sanitary impacts related to bovine mastitis in dairy production as well as on the basis of the restrictions on the use of antibiotics as a means of treatment of this pathology. Its objective is the development of phage-based...
Walbiostent
Study of interaction between stent, arterial wall and blood related to atherosclerosis disease. This project will target 2 main aspects, on the one hand the metal effect on thrombogenecity, which leads to hyperplasia and restenosis, on the other hand the effect of the multilayer stent on the shear stress flow...
Win-TPS
Tools and methods towards the exploitation of a cyclotron-based hadrontherapy facility Hadrontherapy aims at treating cancers by irradiating tumor cells with protons or light ions (carbon), offering increased precision and significant biological gain on specific tumor cases. IBA is designing a new machine capable of treating patients with protons and...
